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Assistant Project Scientist Positions in Pulmonary - Kulkarni Lab 2025-2026
University of California Los Angeles
Details
Posted: 10-Jan-26
Location: Los Angeles, California
Type: Full-time
Categories:
Academic/Faculty
Medical - Research
Internal Number: 6842249
University of California Los Angeles
Requisition Number: JPF10509
The Division of Pulmonary, Critical Care, and Sleep Medicine, in the Department of Medicine at the David Geffen School of Medicine at UCLA, has openings for full-time Assistant Project Scientists.
This position is intended for collaborative research working on lung injury, using a combination of in vitro systems, mouse models and human biospecimens. The study will initially concentrate on how complement proteins modulate the cellular response to injury. The candidate's work will focus on: 1) investigating immune responses at mucosal surfaces such as the lung and the gut using techniques such spectral flow cytometry, proteomic assays, confocal microscopy, and in vivo imaging in conditional knockout mouse models; 2) performing unbiased screens (such as CRISPR and high-throughput compound screens) to identify targets for modulating complement activity; 3) in vitro studies such as site-directed mutagenesis and immunoprecipitation-mass spectrometry to identify binding partners for proteins and how these affect cellular responses to stress; and, 4) developing new ex vivo models from human lung specimens for investigating the pathogenesis of lung injury and repair. with the goal of applying these techniques towards drug discovery. The candidate must also be able to analyze and interpret said data and use these to generate new ideas and hypotheses to move the project/field forward. Experience in analyzing unbiased datasets (for example, transcriptomic or proteomic data) and/or a background in structural biology is looked upon favorably.
The Assistant Project Scientist will work in the Kulkarni Lab and serve as a lead for basic-translational lung injury project(s). The position involves in-person work in the Kulkarni Lab situated in the Clinical Health Sciences building at UCLA. The applicant will meet regularly with their PI, Dr. Kulkarni and other members of the lung injury working group. Responsibilities include: supporting the PI in the design and execution of funded projects by leading investigations in animal models of injury; developing new ex vivo models using mammalian lung tissue (including humans); incorporating new techniques into the workflow of the lab (e.g. multispectral flow cytometry, high throughput screening using cellular imaging, in vivo imaging in animals), tissue analysis by biochemical, proteomic, transcriptomic, metabolic and immunohistological approaches. The candidate will be responsible for identifying the best ways to execute the proposed questions being studied in the lab (along with the PI), identifying appropriate reagents to develop new techniques and assays and implementing and refining them to answer key questions, and perform logical series of experiments to develop understanding of the mechanism of action of intracellular and locally acting complement proteins, among other components of the host response. They will be responsible for co-mentoring other trainees in the lab, as well as assisting junior postdoctoral fellows, graduate students and undergraduate student researchers. Additional responsibilities include: Maintenance of laboratory logs and protocols to be compliant with UCLA protocols, preparing manuscripts for publication in scientific journals, and assisting the PI with the preparation of grant proposals.
Required Qualifications:
Required Skills:
Specific Responsibilities:
The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what's right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.
To apply, please visit: https://recruit.apo.ucla.edu/JPF10509
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy, https://policy.ucop.edu/doc/4000376/DiscHarassAffirmAction
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UCLA is known worldwide for the breadth and quality of its academic, research, health care, cultural, continuing education and athletic programs. UCLA offers undergraduate degrees in more than 127 majors and graduate degrees in 198 program areas. UCLA has 11 highly regarded professional schools. Eight are ranked among the nation's top 15 in their field by U.S. News & World Report. UCLA is consistently among the most popular campus in the nation for undergraduate applicants. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, national origin, disability, or protected veteran status. Benefits:UCLA offers a comprehensive benefits package, including an average of three weeks' vacation per year; an average of 12 days per year sick leave; 13 paid holidays per year; health, dental and optical benefits; life insurance; disability insurance; the University of California Retirement Plan with 5 year vesting and various voluntary UC Savings Plans. There are also special programs and privileges available, such as accessibility to cultural and recreational programs, athletic events, and the University Credit Union.
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